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关于我们

  我们的研发团队经验丰富,技术全面,能够为客户提供动物模型完整解决方案:从上游的基因靶点选定、载体构建、TALEN辅助基因打靶、胚胎干细胞的电转和筛选,到下游的原核注射、胚胎嵌合(8-cell注射、囊胚注射和四倍体胚胎补偿技术等)、核移植和胚胎移植,以及产生小鼠的遗传鉴定与表型分析等服务。


• 具备分子生物学实验室、显微操作室、万级净化细胞间到SPF动物房,可以灵活地为客户量身订做服务。

• 已经建立了打靶ES细胞库(约2000种),质粒库,细胞库,小鼠胚胎库和精子库(约750种)。

• 公司拥有自建的,经验证具有高效种系传递能力的C57BL/6背景的ES细胞系和iPS细胞系。

 

模型研究领域获得的专利:



发表的文章:

1. Simple and efficient production of mice derived from embryonic stem cells aggregated with tetraploid embryos. Li X, Yu Y, Wei W, et al. Mol Reprod Dev. 2005 Jun;71(2):154-8.

2. The proteasomal inhibitor MG132 increases the efficiency of mouse embryo production after cloning by electrofusion. Yu Y, Yong J, Li X, et al. Reproduction. 2005 Oct;130(4):553-8.

3. NestinnegCD24low/- population from fetal Nestin-EGFP transgenic mice enriches the pancreatic endocrine progenitor cells. Wang X, Hu J, Zhao D, et al. Ding M. Pancreas. 2005 Nov;31(4):385-91.

4. Live offspring produced by mouse oocytes derived from premeiotic fetal germ cells. Shen W, Zhang D, Qing T, et al. Biol Reprod. 2006 Oct;75(4):615-23. Epub 2006 May 24.

5. Mouse oocytes derived from fetal germ cells are competent to support the development of embryos by in vitro fertilization. Shen W, Li L, Zhang D, et al. Mol Reprod Dev. 2006 Oct;73(10):1312-7. Erratum in: Mol Reprod Dev. 2008 Nov;75(11):1688-9.

6. Serial nuclear transfer improves the developmental potential of mouse embryos cloned from oocytes matured in a protein-free medium. Bai Z, Yong J, Qing T, et al. Mol Reprod Dev. 2007 May;74(5):560-7.

7. Identification and characterization of label-retaining cells in mouse pancreas. Teng C, Guo Y, Zhang H, et al. Differentiation. 2007 Oct;75(8):702-12. Epub 2007 Mar 23.

8. Induction of oocyte-like cells from mouse embryonic stem cells by co-culture with ovarian granulosa cells. Qing T, Shi Y, Qin H, et al. Differentiation. 2007 Dec;75(10):902-11. Epub 2007 May 9.

9. In vitro development of mouse fetal germ cells into mature oocytes. Shen W, Li L, Bai Z, Pan Q, et al. Reproduction. 2007 Aug;134(2):223-31.

10. Mature oocytes derived from purified mouse fetal germ cells. Qing T, Liu H, Wei W, et al. Hum Reprod. 2008 Jan;23(1):54-61. Epub 2007 Nov 13.

11. A human endothelial cell feeder system that efficiently supports the undifferentiated growth of mouse embryonic stem cells. Zhou H, Yong J, Sun X, et al. .Differentiation. 2008 Nov;76(9):923-30. doi: 10.1111/j.1432-0436.2008.00280.x. Epub 2008 Jun 13.

12. Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains. Yang W, Wei W, Shi C, et al. Stem Cells. 2009 Feb;27(2):383-9. doi: 10.1634/stemcells.2008-0974.

13. Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling. Tong Z, Fan Y, Zhang W, et al. Cell Res. 2009 Jun;19(6):710-9. doi: 10.1038/cr.2009.42.

14. A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation. Song X, Guo Y, Duo S, et al. Am J Pathol. 2009 Nov;175(5):1975-83. doi: 10.2353/ajpath.2009.090349. Epub 2009 Oct 1.

15. P21cip-overexpression in the mouse beta cells leads to the improved recovery from streptozotocin-induced diabetes. Yang J, Zhang W, Jiang W, S et al. PLoS One. 2009 Dec 17;4(12):e8344. doi: 10.1371/journal.pone.0008344.

16. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Li Y, Zhang Q, Yin X, et al. Cell Res. 2011 Jan;21(1):196-204. doi: 10.1038/cr.2010.142. Epub 2010 Oct 19.

17. Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. Chen MHuang JDDeng HK, et al. BMC Cancer. 2011 May 26;11:199. doi: 10.1186/1471-2407-11-199.

18. The heterogeneity and dynamic equilibrium of rat embryonic stem cells. Shen Y, Shi C, Wei W, et al. Cell Res. 2011 Jul;21(7):1143-7. doi: 10.1038/cr.2011.98. Epub 2011 Jun 14.

19. Induction of pluripotency in mouse somatic cells with lineage specifiers. Shu J, Wu C, Wu Y, et al. Cell. 2013 May 23;153(5):963-75. doi: 10.1016/j.cell.2013.05.001.

20. Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds