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iHep-URG

从人其他组织类型细胞诱导分化而来的类肝细胞可以重建URG小鼠肝脏,并且表达各种人肝细胞的功能性的标志基因,为建立人源化肝脏小鼠找到新的人源细胞来源。

 


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图1 URG小鼠应用于诱导分化的人肝细胞(hiHep)的体内功能验证。

 

 

应用领域

-URG® 小鼠和肝脏人源化URG® 小鼠可以用于人特有的肝病、药物安全性评估和人特异的肝脏代谢酶相关的研究;

-HBV,HCV感染研究;

-药物代谢与药物相互作用研究;

-干细胞研究;

-基因治疗研究。

 

参考文献

(1)Xijun Song,Yushan Guo,Shuguang Duo,Jie Che,Chen Wu,Takahiro Ochiya,Mingxiao Ding,Hongkui Deng.A Mouse Model of Inducible Liver Injury Caused by Tet-On Regulated Urokinase for Studies of Hepatocyte Transplantation.The American Journal of Pathology.Volume 175, Issue 5, November 2009, Pages 1975-1983.

2Du Y., Wang J., Jia J., Song N., Xiang C., Xu J., Hou Z., Su X., Liu B.,Jiang T., et al. (2014). Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. Cell Stem Cell, 14,394–403.

3Xie B., Sun D., Du Y., et al. A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts. Cell Res. 2019 Sep;29(9):696-710.

4Feng J., Yang G., Liu Y., et al. LncRNA PCNAP1 modulates hepatitis B virus replication and enhances tumor growth of liver cancer. Theranostics. 2019 Jul 9;9(18):5227-5245.