Basic Information
Strain Establishment
In the severely immunodeficient mice NPG, the mouse Hr gene-specific sgRNA (single-guide RNA) was used to guide Cas9 nuclease to cut the genome, causing DSBs (Double-Stranded Breaks). Through the NHEJ (Non-homologous end Joining) repair pathway, the two cuts were directly ligated, resulting in a frameshift mutation, which achieved the goal of knocking out the Hr gene. Mice of this strain lack T, B, and NK cells, have a functional loss of Hr, and are hairless.
Application Fields of B6-Hairless Mice
1. Dermatological research
2. Humanized tissue or cell transplantation
3. Human cancer research
4. Human hematopoietic system and immune system research
5. Stem cell research
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