General Information
Strain Name | B6-Krastm1(LSL-G12D)Trp53tm1(LSL-R172H)Tg(Pdx1-Cre)/Vst |
Common Name | KPC |
Source | Beijing Vitalstar Biotechnology Co., Ltd. |
Background | C57BL/6N |
Fur Color | Black |
Edited Gene | Kras (Kirsten rat sarcoma viral oncogene homolog); Trp53 (transformation related protein 53) |
Development
Kras is an oncogene, and mutations in the Kras gene are one of the most common drivers of cancer development. The KRAS G12D mutation is the most frequent type of mutation found in pancreatic and colorectal cancers and is also widely present in lung and rectal cancers.
Trp53 is a tumor suppressor gene, and mutations in Trp53 are closely related to tumor metastasis. The most common mutation in human TP53 in cancers is R175H. The mouse Trp53 R172H mutation is highly homologous to the human TP53 R175H mutation, both promoting tumor development and metastasis.
Pdx-Cre mice are mice with pancreas-specific Cre recombinase expression. Under the control of the Pdx promoter, these mice use the Cre recombinase to specifically delete the Loxp-Stop-Loxp (LSL) gene silencing elements in the pancreatic tissue, allowing the Kras G12D and Trp53 R172H mutant genes to be specifically expressed in the pancreas, thereby inducing pancreatic cancer.
Application Fields of KPC Mice
1. Spontaneous pancreatic cancer model
animalmodel@vital-bj.com
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