General Information

Development

Using the CRISPR-Cas9 assisted method, the mouse TIGIT gene was replaced with the human TIGIT. In this way, in the humanized TIGIT mice, human TIGIT antibody inhibitors can be recognized and used for related efficacy or drug screening experiments.

hTIGIT Mice Applications

1. TIGIT-related pharmacodynamic or drug screening experiments

2. Research on TIGIT-targeted immunomodulation for anti-tumor, anti-infection, anti-autoimmune diseases and organ transplantation survival

3. Humanization and cancer therapy

4. Immunotherapy

Reference

1. Yu X, Harden K, Gonzalez LC, et al. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol. 2009, 10(1):48-57.

2. Stengel KF, Harden-Bowles K, Yu X, et al. Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering. Proc Natl Acad Sci U S A. 2012, 109(14):5399-5404.