General Information
Strain Name | B6-Hairlessem1/Vst |
Common Name | B6-Hr, B6-Hairless |
Source | Beijing Vitalstar Biotechnology Co., Ltd. |
Background | C57BL/6N |
Fur Color | Black |
Edited Gene | Hr (Hairless) |
Strain Establishment
In C57 mice, the Hairless gene (Hr) was targeted by mouse Hr gene-specific sgRNA (single-guide RNA) to facilitate Cas9 nuclease cutting of the genome, causing DSBs (Double-Stranded Breaks). Through the NHEJ (Non-homologous end Joining) repair pathway, the two cuts were directly ligated, resulting in a frameshift mutation, which achieved the goal of knocking out the Hr gene. Mice of this strain have a functional loss of Hr and are hairless.
Application Fields of B6-Hairless Mice
1. Dermatological research
2. Human cancer research
3. Human immunology research
4. Regenerative medicine and stem cell research
animalmodel@vital-bj.com
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