General Information
Strain Name | B6-Tg（prAPOE-hCYP3A4）/Vst |
Common Name | liver hCYP3A4 |
Source | Beijing Vitalstar Biotechnology Co., Ltd. |
Background | C57BL/6N |
Fur Color | Black |
Development
In C57 mice, the hCYP3A4 encoding sequence driven by the human APOE gene promoter was injected into mouse fertilized eggs using random transgenesis, ultimately resulting in mice expressing hCYP3A4 in the liver.
Application Fields of Liver hCYP3A4 Mice
1. Studying the metabolic processes of drugs in the liver, especially those metabolized by the CYP3A4 enzyme.
2. Investigating the metabolism of specific drugs or compounds in hCYP3A4 mice to assess their toxicity and safety.
3. Screening and optimizing candidate drugs targeting liver CYP3A4, evaluating their pharmacokinetic properties.
animalmodel@vital-bj.com
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